There are two types of Hodgkin lymphoma. About 95 percent of all cases are classical (or classic) Hodgkin lymphoma. This form of the disease is divided into four subtypes:
Nodular sclerosis: This is the most common sub-type of classical Hodgkin lymphoma. It often occurs in children and young adults, especially young women, and is most often found in the chest and/or neck. This sub-type may cause fibrous scars in the lymph nodes.
Mixed cellularity: This accounts for about 25 percent of all classical Hodgkin lymphoma cases and is more common among older adults. This sub-type is often found in the abdomen.
Lymphocyte-rich: This form of Hodgkin lymphoma accounts for 5 percent of all classical cases and is most often diagnosed in men.
Lymphocyte-depleted: This extremely rare disease represents less than 1 percent of all Hodgkin lymphomas and is most often diagnosed in older adults or people with HIV.
A less common type is nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), which affects about 5 percent of Hodgkin lymphoma patients. NLPHL is characterized by the presence of so-called popcorn cells, lobular versions of Reed-Sternberg cells that resemble popcorn. NLPHL is most often diagnosed in middle-aged adults.
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