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Adrenal cancer risk factors

Risk factors for adrenal cancer may vary. Like many cancer types, the risk for developing adrenal cancer may increase as a result of certain lifestyles and environmental factors, including smoking and exposure to carcinogens. Genetic syndromes have been linked to adrenal cancer.

A rare form of adrenal cancer called pheochromocytoma is largely found in middle-aged adults. Although genetic syndromes and hereditary traits have been linked to adrenal cancer, most adrenal cancers occur sporadically and triggers for the disease remain largely unknown.

Some genetic syndromes considered risk factors for adrenal cancer include:

  • Li-Fraumeni syndrome
  • Von Hippel-Lindau disease
  • Multiple endocrine neoplasia type 1 and 2 (MEN1, MEN2)
  • Beckwith-Wiedemann syndrome

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