Risk factors for bone cancer may vary.
The exact causes of bone cancer are unknown, but certain factors may increase a person"s risk of developing bone cancer. Some examples are genetic disorders and previous treatments for other conditions.Genetic disorders
Several hereditary syndromes caused by mutations in specific genes are considered risk factors for bone cancer, including:
Learn more about genetic counseling and genetic testingOther conditions
Paget"s disease: This non-cancerous condition causes the bones to become thick and brittle, and to break easily. Paget’s disease has been associated with bone cancer in approximately 1 percent of individuals. (Note: Paget’s disease of the breast, a rare form of breast cancer, is medically unrelated to Paget’s disease of the bone.)
Multiple enchondromatosis: Patients with many benign cartilage tumors, known as enchondromas, are at increased risk for developing chondrosarcoma.Previous treatment
Radiation: Exposing bones to high doses of radiation, such as the type of radiation therapy used in cancer treatments, may increase the risk of a primary bone cancer forming in those areas. This risk is higher in young adults. Radioactive minerals such as radium or strontium can build up in the bones and may also cause primary bone cancers.
Bone marrow transplantation: Individuals who have undergone a bone marrow transplant for the treatment of another condition may be at an increased risk for developing osteosarcoma.
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